Enzyme Details

EC Classification

1.14.13.54

Enzyme name
(recommended)

ketosteroid monooxygenase

Alternative names

ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)
steroid-ketone monooxygenase
progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)
17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)
androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With NADH or NADPH as one donor, and incorporation of one atom of oxygen

Catalyses reactions

H+ + NADPH + O2 + Progesterone <-> H2O + NADP+ + Testosterone acetate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.13.54