Enzyme Details

EC Classification

1.14.13.39

Enzyme name
(recommended)

nitric-oxide synthase

Alternative names

NADPH-diaphorase
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
nitric oxide synthetase
endothelium-derived relaxation factor-forming enzyme
endothelium-derived relaxing factor synthase
NO synthase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With NADH or NADPH as one donor, and incorporation of one atom of oxygen

Catalyses reactions

H+ + NADPH + O2 + 2 N-(omega)-Hydroxyarginine <-> NADP+ + 2 L-Citrulline + 2 Nitric oxide

H+ + L-Arginine + NADPH + O2 <-> NADP+ + L-Citrulline + Nitric oxide

H+ + L-Arginine + NADPH + O2 <-> H2O + NADP+ + N-(omega)-Hydroxyarginine

NADH + 2 Hexacyanoferrate(III) <-> NAD+ + H+ + 2 Hexacyanoferrate(II)

NADPH + 2 Hexacyanoferrate(III) <-> H+ + NADP+ + 2 Hexacyanoferrate(II)

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.13.39