Enzyme Details
EC Classification
1.13.11.52
Enzyme name
(recommended)
indoleamine 2,3-dioxygenase
Alternative names
D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
IDO (ambiguous)
tryptophan pyrrolase (ambiguous)
Classification
Oxidoreductases
Acting on single donors with incorporation of molecular oxygen
With incorporation of two atoms of oxygen
Catalyses reactions
L-Tryptophan + O2 <-> L-Formylkynurenine
O2 + 5-Hydroxy-L-tryptophan <-> 5-Hydroxy-N-formylkynurenine
O2 + Serotonin <-> Formyl-5-hydroxykynurenamine
O2 + D-Tryptophan <-> N-Formyl-D-kynurenine
O2 + 5-Hydroxy-D-tryptophan <-> 5-Hydroxy-N-formylkynurenine
O2 + Tryptamine <-> Formylkynurenamine
L-Tryptophan + O2 <-> Formylkynurenine
O2 + L-1-Methyltryptophan <-> N-Formyl-methyl-L-kynurenine
L-Tryptophan + Fe3+ + Heme + Tryptophan 2,3-dioxygenase <-> Enzyme-ferric Fe(III) heme-Tryptophan complex
O2 + 5-Methoxy-DL-tryptophan <-> 5-Methoxy-N-formylkynurenine
O2 + 5-Methyltryptophan <-> 5-Methyl-N-formylkynurenine
O2 + 6-Methyltryptophan <-> 6-Methyl-N-formylkynurenine
O2 + 5-Fluorotryptophan <-> 5-Fluoro-N-formylkynurenine
O2 + 1-Methyl-D-tryptophan <-> N-Formyl-methyl-D-kynurenine
Fe3+ + Cyanide + Heme + Indoleamine 2,3-dioxygenase <-> Enzyme-ferric Fe(III) heme-Cyanide complex
L-Tryptophan + Enzyme-ferric Fe(III) heme-Cyanide complex <-> Enzyme-ferric Fe(III) heme-Cyanide-Tryptophan complex
O2 + Fe2+ + Heme + Indoleamine 2,3-dioxygenase <-> Enzyme-ferrous Fe(II) heme-O2 complex
L-Tryptophan + Fe3+ + Heme + Indoleamine 2,3-dioxygenase <-> Enzyme-ferric Fe(III) heme-Tryptophan complex
L-Tryptophan + Fe2+ + Heme + Indoleamine 2,3-dioxygenase <-> Enzyme-ferrous Fe(II) heme-Tryptophan complex
Cyanide + Enzyme-ferric Fe(III) heme-Tryptophan complex <-> Enzyme-ferric Fe(III) heme-Cyanide-Tryptophan complex
Carbon monoxide + Enzyme-ferrous Fe(II) heme-Tryptophan complex <-> Enzyme-ferrous Fe(II) heme-CO-Tryptophan complex
L-Tryptophan + Enzyme-ferrous Fe(II) heme-CO-Tryptophan complex <-> Enzyme-ferrous Fe(II) heme-CO-(Tryptophan)2 complex
Fe3+ + 5-Hydroxy-L-tryptophan + Heme + Indoleamine 2,3-dioxygenase <-> Enzyme-ferric Fe(III) heme-5-Hydroxy-L-tryptophan complex
Fe2+ + 5-Hydroxy-L-tryptophan + Heme + Indoleamine 2,3-dioxygenase <-> Enzyme-ferrous Fe(II) heme-5-Hydroxy-L-tryptophan complex
External links
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
View all entries for EC Class:
1.13.11.52
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