Enzyme Details

 EC Classification 1.13.11.11
 Enzyme name
(recommended)		 tryptophan 2,3-dioxygenase
 Alternative names L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
tryptophan pyrrolase (ambiguous)
tryptophanase
tryptophan oxygenase
tryptamine 2,3-dioxygenase
tryptophan peroxidase
indoleamine 2,3-dioxygenase (ambiguous)
indolamine 2,3-dioxygenase (ambiguous)
L-tryptophan pyrrolase
TDO
L-tryptophan 2,3-dioxygenase
 Classification
Oxidoreductases
Acting on single donors with incorporation of molecular oxygen
With incorporation of two atoms of oxygen
 Catalyses reactions
L-Tryptophan + O2 <-> Formylkynurenine
L-Tryptophan + O2 <-> L-Formylkynurenine
O2 + 6-Methyltryptophan <-> 6-Methyl-N-formylkynurenine
O2 + 5-Methyltryptophan <-> 5-Methyl-N-formylkynurenine
O2 + 5-Fluorotryptophan <-> 5-Fluoro-N-formylkynurenine
O2 + 6-Fluorotryptophan <-> 6-Fluoro-N-formylkynurenine
L-Tryptophan + Fe3+ + Heme + Tryptophan 2,3-dioxygenase <-> Enzyme-ferric Fe(III) heme-Tryptophan complex
L-Tryptophan + Fe2+ + Heme + Tryptophan 2,3-dioxygenase <-> Enzyme-ferrous Fe(II) heme-Tryptophan complex
Fe3+ + Heme + 6-Fluorotryptophan + Tryptophan 2,3-dioxygenase <-> Enzyme-ferric Fe(III) heme-Fluorotryptophan complex
Fe3+ + Heme + 5-Fluorotryptophan + Tryptophan 2,3-dioxygenase <-> Enzyme-ferric Fe(III) heme-Fluorotryptophan complex
Fe2+ + Heme + 6-Fluorotryptophan + Tryptophan 2,3-dioxygenase <-> Enzyme-ferrous Fe(II) heme-Fluorotryptophan complex
Fe2+ + Heme + 5-Fluorotryptophan + Tryptophan 2,3-dioxygenase <-> Enzyme-ferrous Fe(II) heme-Fluorotryptophan complex
Fe2+ + Heme + Indole-3-propionic acid + Tryptophan 2,3-dioxygenase <-> Enzyme-ferrous Fe(II) heme-Indolepropionic acid complex
Fe2+ + Heme + Tryptophan 2,3-dioxygenase + alpha-Methyltryptophan <-> Enzyme-ferrous Fe(II) heme-Tryptophan complex
O2 + L-1-Methyltryptophan <-> N-Formyl-methyl-L-kynurenine
O2 + D-Tryptophan <-> N-Formyl-D-kynurenine
Fe3+ + Cyanide + Heme + Tryptophan 2,3-dioxygenase <-> Enzyme-ferric Fe(III) heme-Cyanide complex
Fe2+ + Carbon monoxide + Heme + Tryptophan 2,3-dioxygenase <-> Enzyme-ferrous Fe(II) heme-CO complex
Carbon monoxide + Enzyme-ferrous Fe(II) heme-Tryptophan complex <-> Enzyme-ferrous Fe(II) heme-CO-Tryptophan complex
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.13.11.11



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