Enzyme Details

 EC Classification 1.1.1.86
 Enzyme name
(recommended)		 ketol-acid reductoisomerase
 Alternative names (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
dihydroxyisovalerate dehydrogenase (isomerizing)
acetohydroxy acid isomeroreductase
ketol acid reductoisomerase
alpha-keto-beta-hydroxylacyl reductoisomerase
2-hydroxy-3-keto acid reductoisomerase
acetohydroxy acid reductoisomerase
acetolactate reductoisomerase
dihydroxyisovalerate (isomerizing) dehydrogenase
isomeroreductase
reductoisomerase
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
H+ + NADPH + 2-Acetolactate <-> NADP+ + 2,3-Dihydroxy-3-methylbutanoate
NADP+ + (R)-2,3-Dihydroxy-3-methylbutanoate <-> H+ + NADPH + (S)-2-Acetolactate
NADP+ + (R)-2,3-Dihydroxy-3-methylbutanoate <-> H+ + NADPH + (R)-3-Hydroxy-3-methyl-2-oxobutanoate
NADP+ + (R)-2,3-Dihydroxy-3-methylpentanoate <-> H+ + NADPH + (S)-2-Hydroxy-3-methyl-3-oxopentanoate
(S)-2-Aceto-2-hydroxybutanoate <-> (S)-2-Hydroxy-3-methyl-3-oxopentanoate
(S)-2-Acetolactate <-> (R)-3-Hydroxy-3-methyl-2-oxobutanoate
NADP+ + D-Glycerate <-> H+ + NADPH + 3-Hydroxypyruvate
NADP+ + (R)-2,3-Dihydroxy-3-methylbutanoate <-> H+ + NADPH + 3-Hydroxy-3-methyl-2-oxobutanoate
2-Acetolactate <-> 3-Hydroxy-3-methyl-2-oxobutanoate
NADP+ + (R)-Pantoate <-> H+ + NADPH + 2-Dehydropantoate
H+ + NADPH + alpha-Ketovaline <-> NADP+ + Hydroxyisovalerate
H+ + NADPH + 2-Oxopentanoate <-> NADP+ + D-2-Hydroxyvalerate
H+ + NADPH + 2-Oxobutyrate <-> NADP+ + D-2-Hydroxybutyrate
Pyruvate + H+ + NADPH <-> NADP+ + D-Lactate
H+ + NADPH + 3-Hydroxy-2-oxobutanoate <-> NADP+ + Tartrate
NADH + H+ + 2-Acetolactate <-> NAD+ + 2,3-Dihydroxy-3-methylbutanoate
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.1.1.86



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