Enzyme Details

EC Classification

1.1.1.85

Enzyme name
(recommended)

3-isopropylmalate dehydrogenase

Alternative names

(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
beta-isopropylmalic enzyme
beta-isopropylmalate dehydrogenase
threo-Ds-3-isopropylmalate dehydrogenase
3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + 3-Isopropylmalate <-> NADH + H+ + 3-Carboxy-4-methyl-2-oxopentanoate

NAD+ + 3-Isopropylmalate <-> NADH + H+ + CO2 + 4-Methyl-2-oxopentanoate

NAD+ + 3-Ethylmalate <-> NADH + H+ + CO2 + 2-Oxopentanoate

NAD+ + 3-tert-Butylmalate <-> NADH + H+ + CO2 + 2-Hydroxy-4,4-dimethylpentanoate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.85