Enzyme Details

 EC Classification 1.1.1.49
 Enzyme name
(recommended)
glucose-6-phosphate dehydrogenase
 Alternative names D-glucose-6-phosphate:NADP+ 1-oxidoreductase
NADP-glucose-6-phosphate dehydrogenase
Zwischenferment
D-glucose 6-phosphate dehydrogenase
glucose 6-phosphate dehydrogenase (NADP)
NADP-dependent glucose 6-phosphate dehydrogenase
6-phosphoglucose dehydrogenase
Entner-Doudoroff enzyme
glucose-6-phosphate 1-dehydrogenase
G6PDH
GPD
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
NADP+ + beta-D-Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone
NADP+ + D-Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone
NADP+ + Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone
Glucose 6-phosphate + thio-NADP+ <-> H+ + 6-Phospho-D-glucono-1,5-lactone + thio-NADPH
Glucose 6-phosphate + thio-NAD+ <-> H+ + 6-Phospho-D-glucono-1,5-lactone + thio-NADH
NADP+ + D-Galactose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-galactono-1,5-lactone
NADP+ + 2-Deoxy-D-glucose 6-phosphate <-> H+ + NADPH + 2-Deoxy-6-phospho-D-glucono-1,5-lactone
NAD+ + Glucose 6-phosphate <-> NADH + H+ + 6-Phospho-D-glucono-1,5-lactone
NAD+ + D-Glucose 6-phosphate <-> NADH + H+ + 6-Phospho-D-glucono-1,5-lactone
NAD+ + D-Galactose 6-phosphate <-> NADH + H+ + 6-Phospho-D-galactono-1,5-lactone
NAD+ + 2-Deoxy-D-glucose 6-phosphate <-> NADH + H+ + 2-Deoxy-6-phospho-D-glucono-1,5-lactone
NADP+ + 6-Aminoglucose 6-phosphate <-> H+ + NADPH + 6-Aminoglucono-1,5-lactone
NADP+ + sn-Glycerol 3-phosphate <-> Glycerone phosphate + H+ + NADPH
Glucose 6-phosphate + Nicotinamide hypoxanthine dinucleotide phosphate <-> H+ + 6-Phospho-D-glucono-1,5-lactone + deamino-NADPH
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


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