Enzyme Details

 EC Classification 1.1.1.42
 Enzyme name
(recommended)		 isocitrate dehydrogenase (NADP+)
 Alternative names isocitrate:NADP+ oxidoreductase (decarboxylating)
oxalosuccinate decarboxylase
oxalsuccinic decarboxylase
isocitrate (NADP) dehydrogenase
isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase
NADP-specific isocitrate dehydrogenase
NADP-linked isocitrate dehydrogenase
NADP-dependent isocitrate dehydrogenase
NADP isocitric dehydrogenase
isocitrate dehydrogenase (NADP-dependent)
NADP-dependent isocitric dehydrogenase
triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase
NADP+-linked isocitrate dehydrogenase
IDH (ambiguous)
dual-cofactor-specific isocitrate dehydrogenase
NADP+-ICDH
NADP+-IDH
IDP
IDP1
IDP2
IDP3
 Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
 Catalyses reactions
Oxalosuccinate <-> CO2 + 2-Oxoglutarate
NADP+ + Isocitrate <-> H+ + NADPH + Oxalosuccinate
NADP+ + Isocitrate <-> H+ + NADPH + CO2 + 2-Oxoglutarate
NADP+ + Oxalosuccinate <-> H+ + NADPH + CO2 + 2-Oxoglutarate
H+ + NADPH + 2-Oxoglutarate <-> NADP+ + (R)-2-Hydroxyglutarate
Isocitrate + thio-NADP+ <-> H+ + CO2 + 2-Oxoglutarate + thio-NADPH
NAD+ + Isocitrate <-> NADH + H+ + CO2 + 2-Oxoglutarate
NADP+ + D-Isocitrate <-> H+ + NADPH + CO2 + 2-Oxoglutarate
H+ + NADPH + 2-Oxoglutarate <-> NADP+ + 2-Hydroxyglutarate
NAD+ + Homoisocitrate <-> NADH + H+ + CO2 + 2-Oxoadipate
Clomifene + IDH1 <-> Enzyme-inhibitor complex
IDH1 + Rivaroxaban <-> Enzyme-inhibitor complex
IDH1 + Dasatinib <-> Enzyme-inhibitor complex
IDH1 + Demeclocycline <-> Enzyme-inhibitor complex
AGI-5198 + IDH1 <-> Enzyme-inhibitor complex
IDH1 + 5-[(5-Oxo-2-thioxoimidazolidin-4-ylidene)methyl]pyridin-2-one <-> Enzyme-inhibitor complex
NADPH + IDH1 + 5-[(5-Oxo-2-thioxoimidazolidin-4-ylidene)methyl]pyridin-2-one <-> Enzyme-Ligand-Inhibitor complex
NADPH + IDH1 + 2,6-Bis-((1H-imidazol-1-yl)methyl)-4-(2,4,4-trimethylpentan-2-yl)-phenol <-> Enzyme-Ligand-Inhibitor complex
IDH1 + 2,6-Bis-((1H-imidazol-1-yl)methyl)-4-(2,4,4-trimethylpentan-2-yl)-phenol <-> Enzyme-inhibitor complex
NADPH + IDH1 + 2-(N-[2-(Benzimidazol-1-yl)acetyl]-3-fluoroanilino)-N-cyclohexyl-2-(2-methylphenyl)acetamide <-> Enzyme-Ligand-Inhibitor complex
IDH1 + 2-(N-[2-(Benzimidazol-1-yl)acetyl]-3-fluoroanilino)-N-cyclohexyl-2-(2-methylphenyl)acetamide <-> Enzyme-inhibitor complex
NADPH + IDH1 <-> Enzyme-NADPH complex
NADP+ + IDH1 <-> Enzyme-NADP+ complex
NADP+ + D-threo-Isocitrate <-> H+ + NADPH + CO2 + 2-Oxoglutarate
IDH1 + Fab ID7 <-> Enzyme-ligand complex
IDH1 + Fab ID5 <-> Enzyme-ligand complex
D-Isocitrate + IDH1 <-> Enzyme-ligand complex
NADP+ + L-Malate <-> Pyruvate + H+ + NADPH + CO2
3-Acetylpyridine adenine dinucleotide phosphate + D-Isocitrate <-> H+ + CO2 + 2-Oxoglutarate + Reduced 3-acetylpyridine adenine dinucleotide phosphate
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.1.1.42



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