Enzyme Details

EC Classification

1.1.1.35

Enzyme name
(recommended)

3-hydroxyacyl-CoA dehydrogenase

Alternative names

(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
beta-hydroxyacyl dehydrogenase
beta-keto-reductase
3-keto reductase
3-hydroxyacyl coenzyme A dehydrogenase
beta-hydroxyacyl-coenzyme A synthetase
beta-hydroxyacylcoenzyme A dehydrogenase
beta-hydroxybutyrylcoenzyme A dehydrogenase
3-hydroxyacetyl-coenzyme A dehydrogenase
L-3-hydroxyacyl coenzyme A dehydrogenase
L-3-hydroxyacyl CoA dehydrogenase
beta-hydroxyacyl CoA dehydrogenase
3beta-hydroxyacyl coenzyme A dehydrogenase
3-hydroxybutyryl-CoA dehydrogenase
beta-ketoacyl-CoA reductase
beta-hydroxy acid dehydrogenase
3-L-hydroxyacyl-CoA dehydrogenase
3-hydroxyisobutyryl-CoA dehydrogenase
1-specific DPN-linked beta-hydroxybutyric dehydrogenase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + (3S)-3-Hydroxyacyl-CoA <-> NADH + H+ + 3-Oxoacyl-CoA

NAD+ + (S)-3-Hydroxybutanoyl-CoA <-> NADH + H+ + Acetoacetyl-CoA

NADP+ + (S)-3-Hydroxybutanoyl-CoA <-> H+ + NADPH + Acetoacetyl-CoA

NAD+ + (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <-> NADH + H+ + 2-Methylacetoacetyl-CoA

NAD+ + (S)-3-Hydroxyhexadecanoyl-CoA <-> NADH + H+ + 3-Oxopalmitoyl-CoA

NAD+ + (S)-3-Hydroxytetradecanoyl-CoA <-> NADH + H+ + 3-Oxotetradecanoyl-CoA

NAD+ + (S)-3-Hydroxydodecanoyl-CoA <-> NADH + H+ + 3-Oxododecanoyl-CoA