Enzyme Details

EC Classification

1.1.1.34

Enzyme name
(recommended)

hydroxymethylglutaryl-CoA reductase (NADPH)

Alternative names

(R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
3-hydroxy-3-methylglutaryl-CoA reductase
beta-hydroxy-beta-methylglutaryl coenzyme A reductase
hydroxymethylglutaryl CoA reductase (NADPH)
S-3-hydroxy-3-methylglutaryl-CoA reductase
NADPH-hydroxymethylglutaryl-CoA reductase
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
hydroxymethylglutaryl-CoA reductase (NADPH2)

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

2 NADP+ + Coenzyme A + (R)-Mevalonate <-> 2 H+ + 2 NADPH + 3-Hydroxy-3-methylglutaryl-CoA

2 NAD+ + Coenzyme A + Mevalonate <-> 2 NADH + 2 H+ + 3-Hydroxy-3-methylglutaryl-CoA

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.34