Enzyme Details

EC Classification

1.1.1.27

Enzyme name
(recommended)

L-lactate dehydrogenase

Alternative names

(S)-lactate:NAD+ oxidoreductase
lactic acid dehydrogenase
L(+)-nLDH
L-(+)-lactate dehydrogenase
L-lactic dehydrogenase
L-lactic acid dehydrogenase
lactate dehydrogenase
lactate dehydrogenase NAD+-dependent
lactic dehydrogenase
NAD+-lactate dehydrogenase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + L-Lactate <-> Pyruvate + NADH + H+

NAD+ + L-Malate <-> NADH + H+ + Oxaloacetate

NAD+ + D-Lactate <-> Pyruvate + NADH + H+

NAD+ + D-Glycerate <-> NADH + H+ + 3-Hydroxypyruvate

NAD+ + 2-Hydroxybutyrate <-> NADH + H+ + 2-Oxobutyrate

NAD+ + Phenyllactate <-> NADH + H+ + Phenylpyruvate

NADH + H+ + 2-Oxoadipate <-> NAD+ + 2-Hydroxyadipate

NAD+ + Hydroxymalonate <-> NADH + H+ + Oxomalonate

NAD+ + 3-Mercaptolactate <-> NADH + H+ + 3-Mercaptopyruvate

L-Lactate + 3-Acetylpyridine-adenine dinucleotide <-> Pyruvate + H+ + Reduced 3-acetylpyridine-adenine dinucleotide

NADH + H+ + 2-Oxoglutarate <-> NAD+ + 2-Hydroxyglutarate

NADH + H+ + 4-Methyl-2-oxopentanoate <-> NAD+ + 2-Hydroxyisocaproate

NADH + H+ + 2-Oxopentanoate <-> NAD+ + 2-Hydroxyvalerate

NADH + H+ + Phenylpyruvate <-> NAD+ + 2-Hydroxy-3-phenylpropanoic acid

NADH + H+ + 3-Hydroxypyruvate <-> NAD+ + Glycerate

NADH + H+ + alpha-Ketovaline <-> NAD+ + Hydroxyisovalerate

NAD+ + 2-Oxooctanoate <-> NADH + H+ + 2-Hydroxyoctanoate

NADH + H+ + 2-Oxohexanoate <-> NAD+ + 2-Hydroxyhexanoate

NADH + H+ + 2-Oxo-4-aminobutyrate <-> NAD+ + 4-Amino-2-hydroxybutanoate

NADH + H+ + 6-Amino-2-oxohexanoate <-> NAD+ + 6-Amino-2-hydroxyhexanoate

Pyruvate + H+ + Deamino-NADH <-> L-Lactate + Deamino-NAD+

Pyruvate + H+ + NADPH <-> NADP+ + L-Lactate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.27

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