Enzyme Details

EC Classification

1.1.1.141

Enzyme name
(recommended)

15-hydroxyprostaglandin dehydrogenase (NAD+)

Alternative names

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD+ 15-oxidoreductase
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)
PGDH
11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase
15-OH-PGDH
15-hydroxyprostaglandin dehydrogenase
15-hydroxyprostanoic dehydrogenase
NAD+-specific 15-hydroxyprostaglandin dehydrogenase
prostaglandin dehydrogenase
15-hydroxyprostaglandin dehydrogenase (NAD+)
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + Prostaglandin E2 <-> NADH + H+ + (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate

NADP+ + Prostaglandin E2 <-> H+ + NADPH + (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate

NAD+ + Prostaglandin E2 methyl ester <-> NADH + H+ + 15-Keto-prostaglandin E2 methyl ester

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.141