Enzyme Details

EC Classification

1.1.1.1

Enzyme name
(recommended)

alcohol dehydrogenase

Alternative names

alcohol:NAD+ oxidoreductase
aldehyde reductase
ADH
alcohol dehydrogenase (NAD)
aliphatic alcohol dehydrogenase
ethanol dehydrogenase
NAD-dependent alcohol dehydrogenase
NAD-specific aromatic alcohol dehydrogenase
NADH-alcohol dehydrogenase
NADH-aldehyde dehydrogenase
primary alcohol dehydrogenase
yeast alcohol dehydrogenase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

Ethanol + NADP+ <-> H+ + NADPH + Acetaldehyde

NADP+ + 1,2-Propanediol <-> H+ + NADPH + Lactaldehyde

NAD+ + Ethanol <-> NADH + H+ + Acetaldehyde

NAD+ + Methanol <-> NADH + H+ + Formaldehyde

NAD+ + Primary alcohol <-> NADH + H+ + Aldehyde

NAD+ + Secondary alcohol <-> NADH + H+ + Ketone

NAD+ + Glycerol <-> NADH + H+ + D-Glyceraldehyde

NADP+ + Glycerol <-> H+ + NADPH + Dihydroxyacetone

NAD+ + H2O + Benzaldehyde <-> NADH + H+ + Benzoate

H+ + NADPH + Acetone <-> NADP+ + 2-Propanol

NAD+ + Benzyl alcohol <-> NADH + H+ + Benzaldehyde

NAD+ + Glycol <-> NADH + H+ + Glycolaldehyde

NAD+ + Retinol <-> NADH + H+ + all-trans-Retinal

NAD+ + 1-Propanol <-> NADH + H+ + Propanal

H+ + NADPH + Methylglyoxal <-> NADP+ + Hydroxyacetone

NAD+ + Phenylethyl alcohol <-> NADH + H+ + Phenylacetaldehyde

NAD+ + Indole-3-ethanol <-> NADH + H+ + Indole-3-acetaldehyde

NAD+ + 1-Octanol <-> NADH + H+ + 1-Octanal

NAD+ + 11-cis-Retinol <-> NADH + H+ + 11-cis-Retinal

NAD+ + 3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane <-> NADH + H+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al

NADH + H+ + Butanal <-> NAD+ + 1-Butanol

H+ + NADPH + Butanal <-> NADP+ + 1-Butanol

NAD+ + 3alpha,7alpha,26-Trihydroxy-5beta-cholestane <-> NADH + H+ + 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al

NAD+ + 3,4-Dihydroxyphenylethyleneglycol <-> NADH + H+ + 3,4-Dihydroxymandelaldehyde

NAD+ + 3-Methylbutanol <-> NADH + H+ + 3-Methylbutanal

NAD+ + H2O + Butanal <-> NADH + H+ + Butanoate

H+ + NADPH + Glyceraldehyde <-> NADP+ + Glycerol

H+ + NADPH + Glycolaldehyde <-> NADP+ + Glycol

H+ + NADPH + Propanal <-> NADP+ + 1-Propanol

H2O + NADP+ + Propanal <-> H+ + NADPH + Propanoate

NAD+ + 12-Hydroxydodecanoic acid <-> NADH + H+ + 12-Oxododecanoic acid

NAD+ + 1-Pentanol <-> NADH + H+ + 1-Pentanal

NAD+ + S-(Hydroxymethyl)glutathione <-> NADH + H+ + S-Formylglutathione

NAD+ + 2-Buten-1-ol <-> NADH + H+ + 2-Butenal

NADH + H+ + m-Nitrobenzaldehyde <-> NAD+ + m-Nitrobenzyl alcohol

NAD+ + 1-Hexanol <-> NADH + H+ + Hexanal

NAD+ + (S)-2-Butanol <-> NADH + H+ + 2-Butanone

NADH + H+ + 2-Butanone <-> NAD+ + 2-Butanol

NADP+ + (S)-2-Butanol <-> H+ + NADPH + 2-Butanone

H+ + NADPH + 2-Butanone <-> NADP+ + 2-Butanol

NADH + H+ + Acetone <-> NAD+ + 2-Propanol

NAD+ + 13-cis-Retinol <-> NADH + H+ + 13-cis-Retinal

NAD+ + 7-cis-Retinol <-> NADH + H+ + 7-cis-Retinal

NADH + H+ + 9-cis-Retinal <-> NAD+ + 9-cis-Retinol

NAD+ + Methylcrotyl alcohol <-> NADH + H+ + Methylcrotyl aldehyde

NAD+ + (R)-2-Butanol <-> NADH + H+ + 2-Butanone

H2O + p-Nitrophenyl acetate <-> Acetate + p-Nitrophenol

NADH + H+ + 3-Methylcyclohexanone <-> NAD+ + 3-Methylcyclohexanol

NADH + H+ + p-Anisaldehyde <-> NAD+ + 4-Methoxybenzyl alcohol

NADH + H+ + Cyclopetanone <-> NAD+ + Cyclopentanol

NADH + H+ + 3-Methylbutan-2-one <-> NAD+ + 3-Methylbutan-2-ol

NAD+ + Pentan-3-ol <-> NADH + H+ + 3-Pentanone

NAD+ + 2-Pentanol <-> NADH + H+ + 2-Pentanone

NADP+ + S-(Hydroxymethyl)glutathione <-> H+ + NADPH + S-Formylglutathione

NAD+ + Cyclohexanol <-> NADH + H+ + Cyclohexanone

NADH + H+ + 4-Oxoretinal <-> NAD+ + 4-Oxoretinol

NAD+ + 2-Deoxy-D-ribose <-> Unknown + NADH + H+

NADH + H+ + all-trans-Dehydroretinal <-> NAD+ + 3,4-Didehydroretinol

NAD+ + 4-Hydroxyretinol <-> NADH + H+ + 4-Hydroxyretinal

H+ + NADPH + Acetoin <-> NADP+ + 2,3-Butanediol

NAD+ + 16-Hydroxyhexadecanoic acid <-> NADH + H+ + 16-Oxohexadecanoic acid

NAD+ + 4-Hydroxy-3-methoxy-benzenemethanol <-> NADH + H+ + 4-Hydroxy-3-methoxy-benzaldehyde

NAD+ + 3-Phenyl-1-propanol <-> NADH + H+ + 3-Phenyl-1-propanone

NAD+ + Isobutanol <-> NADH + H+ + 2-Methylpropanal

NADH + H+ + 20-CHO-Leukotriene B4 <-> NAD+ + 20-OH-Leukotriene B4

NAD+ + 5beta-Androstane-3beta-ol-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione

NADH + H+ + 5beta-Androstane-17beta-ol-3-one <-> NAD+ + 5beta-Androstane-3beta,17beta-diol

NADH + H+ + 3-Oxo-5beta-cholanate <-> NAD+ + 3beta-Hydroxy-5beta-cholanate

NAD+ + 3beta-Hydroxy-5beta-pregnane-20-one <-> NADH + H+ + 5beta-Pregnane-3,20-dione

NAD+ + 3beta-Hydroxy-5alpha-pregnane-20-one <-> NADH + H+ + 5alpha-Pregnane-3,20-dione

NADH + H+ + 2-Methylbutanal <-> NAD+ + 2-Methylbutanol

Pyruvate + H+ + NADPH <-> NADP+ + L-Lactate

H+ + NADPH + Hydroxyacetone <-> NADP+ + 1,2-Propanediol

NAD+ + S-(+)-Octan-2-ol <-> NADH + H+ + Octan-2-one

NAD+ + R-(-)-Heptan-2-ol <-> NADH + H+ + Heptan-2-one

NAD+ + R-(+)-cis-Verbenol <-> NADH + H+ + Verbenone

NAD+ + R-(-)-2-Pentanol <-> NADH + H+ + 2-Pentanone

NAD+ + 2-Hexanol <-> NADH + H+ + 2-Hexanone

NAD+ + R-(+)-trans-Bicyclo[2.2.1]heptanol <-> NADH + H+ + Bicyclo[2.2.1]heptanone

NAD+ + R-(-)-2-Hexanol <-> NADH + H+ + 2-Hexanone

NAD+ + S-(-)-2-Methylbutan-1-ol <-> NADH + H+ + S-(-)-2-Methylbutan-1-al

NAD+ + trans-Bicyclo[2.2.1]heptanol <-> NADH + H+ + Bicyclo[2.2.1]heptanone

NAD+ + 1-Phenylethanol <-> NADH + H+ + Acetophenone

NAD+ + cis-4-Methylcyclohexanol <-> NADH + H+ + 4-Methylcyclohexanone

NAD+ + R-(-)-3-Methylbutan-2-ol <-> NADH + H+ + 3-Methylbutan-2-one

NAD+ + S-(+)-2-Hexanol <-> NADH + H+ + 2-Hexanone

NAD+ + Heptan-2-ol <-> NADH + H+ + Heptan-2-one

NAD+ + R-(+)-1-Phenylethanol <-> NADH + H+ + Acetophenone

NAD+ + R-(-)-2-Butanol <-> NADH + H+ + 2-Butanone

NAD+ + 3-Methyl-2-cyclohexanol <-> NADH + H+ + 3-Methyl-2-cyclohexanone

NAD+ + trans-4-Methylcyclohexanol <-> NADH + H+ + 4-Methylcyclohexanone

NAD+ + S-(-)-1-Phenylethanol <-> NADH + H+ + Acetophenone

NAD+ + (S)-(+)-2-Butanol <-> NADH + H+ + 2-Butanone

NAD+ + 4-Methylpentan-1-ol <-> NADH + H+ + 4-Methylpentanal

NAD+ + 4-Heptanol <-> NADH + H+ + 4-Heptanone

NAD+ + S-(+)-3-Methylbutan-2-ol <-> NADH + H+ + 3-Methylbutan-2-one

NAD+ + R-(-)-Octan-2-ol <-> NADH + H+ + Octan-2-one

NAD+ + S-(-)-cis-Bicyclo[2.2.1]heptanol <-> NADH + H+ + Bicyclo[2.2.1]heptanone

NAD+ + S-(+)-Heptan-2-ol <-> NADH + H+ + Heptan-2-one

NAD+ + S-(-)-trans-Bicyclo[2.2.1]heptanol <-> NADH + H+ + Bicyclo[2.2.1]heptanone

H+ + NADPH + 2-Methylpropanal <-> NADP+ + Isobutanol

NADP+ + 2-Pentanol <-> H+ + NADPH + 2-Pentanone

NADP+ + t-Butanol <-> Unknown + H+ + NADPH

NADP+ + 1,2-Butanediol <-> Unknown + H+ + NADPH

NADP+ + 1,3-Butanediol <-> Unknown + H+ + NADPH

NADP+ + (R)-2-Butanol <-> H+ + NADPH + 2-Butanone

NAD+ + 1-Dodecanol <-> NADH + H+ + Dodecanal

NAD+ + (S)-2-Methylbutanol <-> NADH + H+ + (S)-2-Methylbutanal

NADH + S-Nitrosoglutathione <-> NAD+ + Glutathione sulfinamide

NADPH + S-Nitrosoglutathione <-> NADP+ + Glutathione sulfinamide

NADH + H+ + N-Benzyl-3-pyrrolidinone <-> NAD+ + (S)-N-Benzyl-3-pyrrolidinol

NAD+ + (S)-2-Phenylpropanol <-> NADH + H+ + (S)-2-Phenylpropionaldehyde

NAD+ + (R)-2-Phenylpropanol <-> NADH + H+ + (R)-2-Phenylpropionaldehyde

NADH + H+ + 2-Phenylpropionaldehyde <-> NAD+ + 2-Phenylpropanol

NAD+ + 1-Nonanol <-> NADH + H+ + Nonanal

NAD+ + 1-Decanol <-> NADH + H+ + Decanal

NAD+ + 1-Tetradecanol <-> NADH + H+ + Tetradecanal

NAD+ + cis-2-Hexene-1-ol <-> NADH + H+ + cis-2-Hexenal

NAD+ + trans-2-Hexene-1-ol <-> NADH + H+ + trans-2-Hexene-1-al

NAD+ + Prenol <-> NADH + H+ + 3-Methylbut-2-enal

NAD+ + Farnesol <-> NADH + H+ + Farnesal

2 NAD+ + 2-Butene-1,4-diol <-> 2 NADH + 2 H+ + 2-Butendial

2 NAD+ + 1,6-Hexanediol <-> 2 NADH + 2 H+ + 1,6-Hexanedial

2 NAD+ + Octane-1,8-diol <-> 2 NADH + 2 H+ + Octane-1,8-dial

NAD+ + Cinnamyl alcohol <-> NADH + H+ + Cinnamaldehyde

NAD+ + 5beta-cholane-3alpha,7alpha,12alpha,24-tetrol <-> Unknown + NADH + H+

NAD+ + Geraniol <-> NADH + H+ + Geranial

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

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